What is homocysteine?
- Homocysteine is amino acid biosynthesized from methionine.
- In normal, physiological conditions, it is contained in plasma in concentration 5-9 μmol/l.
- Increased concentration of homocysteine causes the speeding up of atherosclerosis process.
- Increased homocysteine level leads to increased risk of unwanted cardiovascular and cerebral episodes.
Role of folate and B group vitamins
VB group vitamins and folate, besides a number of metabolic processes, also regulate level of homocysteine in blood. Intake of folate increased by 100 μg/d reduces the level of homocysteine by 6% and the risk of cardiovascular diseases by 5%.6
Is it sufficient to consume any form of folate?
58% persons in Serbia have innate genetic mutation that leads to folate deficit.5
Only “biologically active form“ of folate, 5-methyltetrahydrofolate, participates in metabolism of homocysteine and lowers its blood value.
- Folate cannot be synthetized in organism.
- It is recommendable to consume biologically active form of folate (5-methyltetrahydrofolate /MTHF).
- Depositing of folate metabolites and inability to convert into 5MTHF form significantly reduced activities of ‘’Natural Killer Cells’’, which represents an additional heath risk.
- 70% persons has vitamin D deficiency.
- Latest researches show that vitamin D is responsible for health of cardio vascular system through various mechanisms.
(Renin-angiotensin system and reduction of inflammatory processes on blood vessels).
Vitamin C with its strong antioxidant effects prevents damages to endothelial cells and migration of inflammatory cells, thus slowing down atherosclerosis process.
- Supports normal heart function – vitamin B1.
- Supports normal metabolism of homocystein – folate, vitamin B6 and B12.
- Support normal creation of collagen for normal blood vessels function – vitamin C.
- Supports protection of cells from oxidative stress – vitamin C.
- Supports reduction of fatigue and exhaustion – vitamin B6, vitamin B12 and vitamin C.
- Supports normal absorbance/ utilization of calcium and phosphorus – vitamin D.
To see list of clinical studies click HERE.