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For physicians

JAMA, March 15, 2015.
The CSPPT, a large randomized trial among adults with hypertension in China without a history of stroke or MI, found that enalapril–folic acid therapy, compared with enalapril alone, significantly reduced the relative risk of first stroke by 21%.16

What is homocysteine?

  • Homocysteine is amino acid biosynthesized from methionine.
  • In normal, physiological conditions, it is contained in plasma in concentration 5-9 μmol/l.
  • Increased concentration of homocysteine causes the speeding up of atherosclerosis process.
  • Increased homocysteine level leads to increased risk of unwanted cardiovascular and cerebral episodes.

Homocistein-CARDIOvitamin-transENl

  • Increased level of homocysteine represents independent risk factor, such as smoking or hypertension, tha cause unwanted cardiovascular and cerebral illnesses.4
  • Level of homocysteine in blood increased to 3 μmol/l increases the risk of occurrence of myocardial infarction by 15% and stroke by 24%.3
  • 28% patients are insufficiently sensitive to therapy with acetylsalicylic acid in protective dosage.1
  • CARDIOvitamin® lowers the level of homocysteine and supports protective and anti-aggregation effect of acetylsalicylic acid.2

Role of folate and B group vitamins

VB group vitamins and folate, besides a number of metabolic processes, also regulate level of homocysteine in blood. Intake of folate increased by 100 μg/d reduces the level of homocysteine by 6% and the risk of cardiovascular diseases by 5%.6

Is it sufficient to consume any form of folate?
58% persons in Serbia have innate genetic mutation that leads to folate deficit.5
Only “biologically active form“ of folate, 5-methyltetrahydrofolate, participates in metabolism of homocysteine and lowers its blood value.

Only “biologically active form“of folate, 5-methyltetrahydrofolate participates in homocysteine metabolism and lowers its blood value.

FolnaKiselinaAktivniOblik-EN

 

  • Folate cannot be synthetized in organism.
  • It is recommendable to consume biologically active form of folate (5-methyltetrahydrofolate /MTHF).
  • Depositing of folate metabolites and inability to convert into 5MTHF form significantly reduced activities of ‘’Natural Killer Cells’’, which represents an additional heath risk.
CARDIOvitamin® contains biologically active form of folate acid 5-MTHF (5-methyltetrahydrofolate).

Cardiovitamin-grafikon

7 x larger

concentration of 5-methyltetrahydrofolate in plasma

Role of vitamin D and vitamin C

  • 70% persons has vitamin D deficiency.
  • Latest researches show that vitamin D is responsible for health of cardio vascular system through various mechanisms.
    (Renin-angiotensin system and reduction of inflammatory processes on blood vessels).
Vitamin D below 15ng/ml from normal value doubles the risk of heart attack and stroke.

Cardiovitamin-grafikon-1EN

Vitamin C with its strong antioxidant effects prevents damages to endothelial cells and migration of inflammatory cells, thus slowing down atherosclerosis process.

  • Consumption of vitamins is a non-toxic and simple way of reducing risk and prevention of cardiovascular diseases!
  • CARDIOvitamin® in synergy with anti aggregation therapy completes the protection of unwanted cardiovascular and cerebrovascular episodes.

 

EFSA

CARDIOvitamin®

  • Supports normal heart function – vitamin B1.
  • Supports normal metabolism of homocystein – folate, vitamin B6 and B12.
  • Support normal creation of collagen for normal blood vessels function – vitamin C.
  • Supports protection of cells from oxidative stress – vitamin C.
  • Supports reduction of fatigue and exhaustion – vitamin B6, vitamin B12 and vitamin C.
  • Supports normal absorbance/ utilization of calcium and phosphorus – vitamin D.

CARDIOvitamin-sastav

To see list of clinical studies click HERE.